Penetration of Lipid Monolayers by Polyene Antibiotics
نویسندگان
چکیده
منابع مشابه
Penetration of Lipid Monolayers by Polyene Antibiotics. Correlation with Selective Toxicity and Mode of Action.
Previous studies have shown that polyene antibiotics alter permeability in sensitive fungi and thus lead to the loss of essential cytoplasmic constituents, which ultimately culminates in cell death (l-3). Subsequent investigations have led to the contention that the selective toxicity of the polyene antibiotics is due to interaction with a component present only in the membrane of sensitive org...
متن کاملPenetration of Lipid Monolayers by Polyene Antibiotics CORRELATIOS WITH SELECTIVE TOXICITY AND MODE OF ACTION*
Previous studies have shown that polyene antibiotics alter permeability in sensitive fungi and thus lead to the loss of essential cytoplasmic constituents, which ultimately culminates in cell death (l-3). Subsequent investigations have led to the contention that the selective toxicity of the polyene antibiotics is due to interaction with a component present only in the membrane of sensitive org...
متن کاملThe Interaction of Polyene Antibiotics with Thin Lipid Membranes
Optically black, thin lipid membranes prepared from sheep erythrocyte lipids have a high dc resistance (R(m) congruent with 10(8) ohm-cm(2)) when the bathing solutions contain NaCl or KCl. The ionic transference numbers (T(i)) indicate that these membranes are cation-selective (T(Na) congruent with 0.85; T(Cl) congruent with 0.15). These electrical properties are independent of the cholesterol ...
متن کاملPolyene Antifungal Antibiotics
ZYGMUNT, WALTER A. (Mead Johnson Research Center, Evansville, Ind.). Intracellular loss of potassium in Candida albicans after exposure to polyene antifungal antibiotics. Appl. Microbiol. 14:953-956. 1966.-Eleven antifungal antibiotics, representing three broad macrolide classes, were studied in Candida albicans for their effect on growth and on the fate of intracellular K+. Marked differences ...
متن کاملThe polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97388-6